jennifer higham genentech

Genentech, a member of the Roche Group, announced the appointment of Alexander Hardy to chief executive officer, effective March 1, 2019. The neutrophil protein CD177 is a novel PDPN receptor that regulates human cancerassociated fibroblast physiology, Antibody toolkit reveals N-terminally ubiquitinated substrates of UBE2W, An Integrated Genomic, Proteomic, and Immunopeptidomic Approach to Discover Treatment-Induced Neoantigens, Discovery of a caspase cleavage motif antibody reveals insights into noncanonical inflammasome function, Machine-learning and chemicogenomics approach defines and predicts cross-talk of hippo and MAPK pathways, Activation of NF-B and p300/CBP potentiates cancer chemoimmunotherapy through induction of MHC-I antigen presentation, Proteomics in the pharmaceutical and biotechnology industry: a look to the next decade, Sensitive and quantitative detection of MHC-I displayed neoepitopes using a semiautomated workflow and TOMAHAQ mass spectrometry, Neutrophil serine protease 4 is required for mast cell-dependent vascular leakage, Integration of innate immune signalling by caspase-8 cleavage of N4BP1, The Immunoglobulin Superfamily Receptome Defines Cancer-Relevant Networks Associated with Clinical Outcome, Data on charge separation of bispecific and mispaired IgGs using native charge-variant mass spectrometry, Development of a therapeutic anti-HtrA1 antibody and the identification of DKK3 as a pharmacodynamic biomarker in geographic atrophy, Mutation position is an important determinant for predicting cancer neoantigens, Proteomic Analyses Identify a Novel Role for EZH2 in the Initiation of Cancer Cell Drug Tolerance, Characterization of bispecific and mispaired IgGs by native charge-variant mass spectrometry, Hippo Pathway in Cancer: Aberrant Regulation and Therapeutic Opportunities, The tumor suppressor BAP1 cooperates with BRAFV600E to promote tumor formation in cutaneous melanoma, Discovery and Qualification of Candidate Urinary Biomarkers of Disease Activity in Lupus Nephritis, A platform for extracellular interactome discovery identifies novel functional binding partners for the immune receptors B7-H3/CD276 and PVR/CD155, MAPPs for the identification of immunogenic hotspots of biotherapeutics; an overview of the technology and its application to the biopharmaceutical arena, Tumor suppressor BAP1 is essential for thymic development and proliferative responses of T lymphocytes, The kinase TPL2 activates ERK and p38 signaling to promote neutrophilic inflammation, De Novo MS/MS Sequencing of Native Human Antibodies, A Common Variant of IL-6R is Associated with Elevated IL-6 Pathway Activity in Alzheimer's Disease Brains, Building proteomic tool boxes to monitor MHC class I and class II peptides, Characterization of chain pairing variants of bispecific IgG Expressed in a single host cell by high-resolution native and denaturing mass spectrometry, RIPK1 inhibits ZBP1-driven necroptosis during development, Rapid, semi-automated protein terminal characterization using ISDetect, Response to comment on "sumo deconjugation is required for arsenic-triggered ubiquitylation of PML", Uncovering a dual regulatory role for caspases during endoplasmic reticulum stress-induced cell death, Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling, IgSimulator: A versatile immunosequencing simulator, Proteomic tools for the characterization of cell death mechanisms in drug discovery, Transcription factor ATF4 induces NLRP1 inflammasome expression during endoplasmic reticulum stress, Ig Repertoire Constructor: A novel algorithm for antibody repertoire construction and immunoproteogenomics analysis, SUMO deconjugation is required for arsenic-triggered ubiquitylation of PML, Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells, HSP105 recruits protein phosphatase 2A To dephosphorylate -catenin, Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing, Stable-isotope-labeled histone peptide library for histone post-translational modification and variant quantification by mass spectrometry, Evolutionary divergence in the catalytic activity of the CAM-1, ROR1 and ROR2 kinase domains, A turn-key approach for large-scale identification of complex posttranslational modifications, Combinatorial approach for large-scale identification of linked peptides from tandem mass spectrometry spectra, Toward understanding ubiquitin-modifying enzymes: From pharmacological targeting to proteomics, Peptide level immunoaffinity enrichment enhances ubiquitination site identification on individual proteins, Complementary methods for the identification of substrates of proteolysis, Endosomes are specialized platforms for bacterial sensing and NOD2 signalling, Phosphoproteomic analysis implicates the mTORC2-FoxO1 axis in VEGF signaling and feedback activation of receptor tyrosine kinases, Phosphorylation of dishevelled by protein kinase RIPK4 regulates Wnt signaling, The chromosome-centric human proteome project: A call to action, TRAF2 Sets a Threshold for Extrinsic Apoptosis by Tagging Caspase-8 with a Ubiquitin Shutoff Timer, Microwave-assisted protein staining, destaining, and in-gel/in-solution digestion of proteins, Loss of the tumor suppressor BAP1 causes myeloid transformation, Complementary proteomic tools for the dissection of apoptotic proteolysis events, Polyubiquitination of insulin-like growth factor I receptor (IGF-IR) activation loop promotes antibody-induced receptor internalization and down-regulation, Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling, Deubiquitinase USP37 Is Activated by CDK2 to Antagonize APCCDH1 and Promote S Phase Entry, Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7, Resurrection of a clinical antibody: Template proteogenomic de novo proteomic sequencing and reverse engineering of an anti-lymphotoxin- antibody, Comparative analysis of techniques to purify plasma membrane proteins, Template proteogenomics: Sequencing whole proteins using an imperfect database, Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival, Targeting interferon alpha subtypes in serum: A comparison of analytical approaches to the detection and quantitation of proteins in complex biological matrices, Cullin3-Based Polyubiquitination and p62-Dependent Aggregation of Caspase-8 Mediate Extrinsic Apoptosis Signaling, The double-histone-acetyltransferase complex ATAC is essential for mammalian development. Because its not.. Leaders are expected to create succession plans for their top-performing team members. Leader; Michael N. Cantor; Anne E. Justice; Dave J. Carey; Geetha Chittoor; Navya Josyula; Jack A. Kosmicki; Julie E. Horowitz; Aris Baras; Matthew C. Gass; Ashish Yadav; Tooraj Mirshahi; Jouke-Jan Hottenga; Meike Bartels; Eco J. C. de Geus; Michel G. Nivard; Anurag Verma; Marylyn D. Ritchie; Daniel J. Rader; Binglan Li; Shefali Setia Verma; Anastasia M. Lucas; Yuki Bradford; Federico Zara; Vincenzo Salpietro; Marcello Scala; Michele Iacomino; Paolo Scudieri; Renata Bocciardi; Carlo Minetti; Antonella Riva; Maria Stella Vari; Jean-Franois Rahier; Elisa Giorgio; Diana Carli; Edouard Louis; Cynthia M. Bulik; Mikael Landn; Alfredo Brusco; Giovanni Battista Ferrero; Francesca Madia; Bengt Fundn; Said I. Ismail; Chadi Saad; Yaser Al-Sarraj; Radja Messai Badji; Wadha Al-Muftah; Asma Al Thani; Nahla Afifi; Janis Klovins; Vita Rovite; Raimonds Rescenko; Raitis Peculis; Monta Ustinova; Hugo Zeberg; Robert Frithiof; Michael Hultstrm; Miklos Lipcsey; Ruth Johnson; Daniel H. Geschwind; Nelson B. Freimer; Manish J. Butte; Yi Ding; Alec Chiu; Timothy S. Chang; Paul Boutros; Loukas Moutsianas; Mark J. Caulfield; Richard H. Scott; Susan Walker; Alex Stuckey; Christopher A. Odhams; Daniel Rhodes; Tom Fowler; Augusto Rendon; Georgia Chan; Prabhu Arumugam; Konrad J. Karczewski; Daniel J. Wilson; Chris A. Spencer; Derrick W. Crook; David H. Wyllie; Anne Marie OConnell; Brent Richards; Elizabeth G. Atkinson; Kristin Tsuo; Nikolas Baya; Patrick Turley; Rahul Gupta; Raymond K. Walters; Duncan S. Palmer; Gopal Sarma; Nathan Cheng; Wenhan Lu; Claire Churchhouse; Jacqueline I. Goldstein; Daniel King; Cotton Seed; Sam Bryant; Kyle Satterstrom; Gavin Band; Sarah G. Earle; Shang-Kuan Lin; Nicolas Arning; Jacob Armstrong; Justine K. Rudkin; Shawneequa Callier; Caroline Cusick; Nicole Soranzo; Jing Hua Zhao; John Danesh; Emanuele Di Angelantonio; Adam S. Butterworth; Yan V. Sun; Jennifer E. Huffman; Kelly Cho; Christopher J. ODonnell; Philip S. Tsao; Michael Gaziano; Gina M. Peloso; Yuk-Lam Ho; Michael Mian; Federica Scaggiante; Xiao Chang; Joseph T. Glessner; Hakon Hakonarson; Peter J. McGuigan; Luke Stephen Prockter Moore; Marcela Paola Vizcaychipi; Kathryn Hall; Andy Campbell; Ailstair Nichol; Geraldine Ward; Valerie Joan Page; Kayode Adeniji; Daniel Agranoff; Ken Agwuh; Dhiraj Ail; Erin L. Aldera; Ana Alegria; Brian Angus; Abdul Ashish; Dougal Atkinson; Shahedal Bari; Gavin Barlow; Stella Barnass; Nicholas Barrett; Christopher Bassford; Sneha Basude; David Baxter; Michael Beadsworth; Jolanta Bernatoniene; John Berridge; Nicola Best; Pieter Bothma; David Chadwick; Robin Brittain-Long; Naomi Bulteel; Tom Burden; Vikki Caruth; Duncan Chambler; Nigel Chee; Jenny Child; Tom Clark; Paul Collini; Catherine Cosgrove; Jason Cupitt; Maria-Teresa Cutino-Moguel; Paul Dark; Chris Dawson; Samir Dervisevic; Phil Donnison; Sam Douthwaite; Andrew Drummond; Ingrid DuRand; Ahilanadan Dushianthan; Tristan Dyer; Cariad Evans; Chi Eziefula; Chris Fegan; Adam Finn; Duncan Fullerton; Sanjeev Garg; Atul Garg; Effrossyni Gkrania-Klotsas; Jo Godden; Arthur Goldsmith; Clive Graham; Elaine Hardy; Stuart Hartshorn; Daniel Harvey; Peter Havalda; Maria Hobrok; Michael Jacobs; Susan Jain; Paul Jennings; Agilan Kaliappan; Vidya Kasipandian; Stephen Kegg; Michael Kelsey; Jason Kendall; Caroline Kerrison; Ian Kerslake; Oliver Koch; Gouri Koduri; George Koshy; Shondipon Laha; Steven Laird; Susan Larkin; Tamas Leiner; Patrick Lillie; James Limb; Vanessa Linnett; Jeff Little; Mark Lyttle; Michael MacMahon; Emily MacNaughton; Ravish Mankregod; Huw Masson; Elijah Matovu; Katherine McCullough; Ruth McEwen; Manjula Meda; Jane Minton; Karl Ward; Mariyam Mirfenderesky; Kavya Mohandas; Quen Mok; James Moon; Elinoor Moore; Patrick Morgan; Craig Morris; Katherine Mortimore; Samuel Moses; Mbiye Mpenge; Rohinton Mulla; Michael Murphy; Megan Nagel; Thapas Nagarajan; Mark Nelson; Matthew K. OShea; Igor Otahal; Marlies Ostermann; Mark Pais; Selva Panchatsharam; Danai Papakonstantinou; Hassan Paraiso; Brij Patel; Natalie Pattison; Justin Pepperell; Mark Peters; Mandeep Phull; Stefania Pintus; Jagtur Singh Pooni; Frank Post; David Price; Rachel Prout; Nikolas Rae; Henrik Reschreiter; Tim Reynolds; Neil Richardson; Mark Roberts; Devender Roberts; Alistair Rose; Guy Rousseau; Brendan Ryan; Taranprit Saluja; Aarti Shah; Prad Shanmuga; Anil Sharma; Anna Shawcross; Jeremy Sizer; Manu Shankar-Hari; Richard Smith; Catherine Snelson; Nick Spittle; Nikki Staines; Tom Stambach; Richard Stewart; Pradeep Subudhi; Jo Thomas; Chris Thompson; Robert Thompson; Ascanio Tridente; Darell Tupper-Carey; Mary Twagira; Andrew Ustianowski; Nick Vallotton; Lisa Vincent-Smith; Shico Visuvanathan; Alan Vuylsteke; Sam Waddy; Rachel Wake; Andrew Walden; Ingeborg Welters; Tony Whitehouse; Paul Whittaker; Ashley Whittington; Padmasayee Papineni; Meme Wijesinghe; Martin Williams; Lawrence Wilson; Sarah Cole; Stephen Winchester; Martin Wiselka; Adam Wolverson; Daniel G. Wooton; Andrew Workman; Bryan Yates; Peter Young; Rupert Beale; Andrew D. Bretherick; Max Head Fourman; James Furniss; Elvina Gountouna; Graeme Grimes; Chris S Haley; David Harrison; Caroline Hayward; Sean Keating; Lucija Klaric; Paul Klenerman; Alison M. Meynert; Jonathan Millar; Erola Pairo-Castineira; Nicholas J. Parkinson; Chris P. Ponting; David Porteous; Konrad Rawlik; Anne Richmond; Clark D. Russell; Xia Shen; Barbara Shih; Albert Tenesa; Veronique Vitart; Bo Wang; James F Wilson; Yang Wu; Jian Yang; Zhijian Yang; Marie Zechner; Ranran Zhai; Chenqing Zheng; Lisa Norman; Riinu Pius; Thomas M. Drake; Cameron J. Fairfield; Stephen R. Knight; Kenneth A. Mclean; Derek Murphy; Catherine A. Shaw; Jo Dalton; Michelle Girvan; Egle Saviciute; Stephanie Roberts; Janet Harrison; Laura Marsh; Marie Connor; Sophie Halpin; Clare Jackson; Carrol Gamble; Gary Leeming; Andrew Law; Murray Wham; Sara Clohisey; Ross Hendry; James Scott-Brown; Colin Begg; Charles Hinds; Antonia Ying Wai Ho; Peter W. Horby; Julian C. Knight; Lowell Ling; David Maslove; Danny McAuley; Hugh Montgomery; Peter J. M. Openshaw; Kathy Rowan; Malcolm G. Semple; Charlotte Summers; Timothy Walsh; Lisa Armstrong; Hayley Bates; Emma Dooks; Fiona Farquhar; Brigid Hairsine; Sophie Packham; Zoe Alldis; Raine Astin-Chamberlain; Fatima Bibi; Jack Biddle; Sarah Blow; Matthew Bolton; Catherine Borra; Ruth Bowles; Maudrian Burton; Yasmin Choudhury; David A. 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