Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. Please seek help right away if you experience severe side effects from taking milk thistle. Silymarin, an active component of milk thistle, may improve liver function and reduce symptoms of cirrhosis, or scarring of the liver. These reactions may occur if you have an allergy to milk thistle. Dosage: How Much Milk Thistle Should I Take? Kawaguchi-Suzuki M, Frye RF, Zhu HJ, et al. Some people also call it Mary thistle and holy thistle. Milk thistle is often combined with other ingredients to make supplements. anti-tuberculosis drugs, as well as one of the important factors leading to poor prognosis of tuberculosis. It may take one or two weeks for milk thistle to start working. Does milk thistle cause any side effects? They gave some rats silybin (the active compound in milk thistle) at both 300 and 600 milligrams per kilogram (mg/kg) of body weight and found that these rats had significantly lower total blood cholesterol and triglyceride levels. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first. Save the high-quality PDF version on your device now. Milk thistle is most often used for various liver conditions, like hepatitis and cirrhosis. Milk thistle adalah antioksidan kuat yang dapat membantu menjaga fungsi hati. A 2013 study found that milk thistle helped to prevent bone loss. Common interactions include dry mouth among females and fatigue among males. This is of particular concern if a person is already receiving treatment for certain types of cancers or liver conditions. Vegetable Oil: Nutrition Fac Olive Oil Vs. Milk thistle ( Silybum marianum L. Mulrow C, Lawrence V, Jacobs B, et al. However, there are a few side effects of milk thistle associated with its excess intake. Milk thistle. Milk thistle has not been implicated in causing liver injury and is still used widely as a liver tonic in patients with acute and chronic liver diseases. However, more direct research is warranted in this regard. Phytother Res. Of the total drug interactions, Thank you, {{form.email}}, for signing up. Should I avoid certain foods while taking Milk Thistle Capsule? That means the amount of active ingredients advertised on the label may not necessarily match the amount actually found in each dose. If you miss a dose, take it as soon as you remember. Take charge of your healthtalk with your health care providers about any complementary health approaches you use. ), SAGE Journals. Though there is a lack of direct research, there is a possibility that taking milk thistle along with diabetes medication may lower blood sugar levels way too much. Achufusi TGO, Patel RK. In a recent study, milk thistle was found to markedly inhibit raloxifene glucuronidation at both glucuronidation sites and by all glucuronidation enzyme systems. Other potential benefits include . Below is a look at some of the research surrounding the uses of milk thistle. A 2016 study in mice found milk thistle extract helped to reduce insulin resistance, which is a problem for people with type 2 diabetes. Does milk thistle interact with my other drugs? This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Click here for additional information. Milk thistle is a natural herb with antioxidant and anti-inflammatory properties. Call your doctor for medical advice about side effects. The review went on to say that silymarin may be linked to lower rates of mortality in patients with cirrhosis and liver disease. There are other supplements that work similarly to milk thistle. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product. Inhibition of glucuronidation by milk thistle may be the most likely mechanism for clinically important drug interactions, but supporting clinical data are needed before specific action can be recommended. Minimally clinically significant. It is unknown if this product passes into breast milk. NCCIH has provided this material for your information. Call your doctor for medical advice about side effects. So, consult a doctor to understand about its long term usage. Silybum (milk thistle) is a genus of two species of thistles in the family Asteraceae. Email this report to a friend, doctor, or patient. If left untreated, anaphylaxis can lead to shock, coma, cardiac or respiratory failure, or even death. To establish that the product manufacturers addressed safety and efficacy standards, we: We do the research so you can find trusted products for your health and wellness. Silymarin as supportive treatment in liver diseases: a narrative review. Include all brand names and combination drug names. Common side effects of milk thistle reported in studies include: Typically, side effects will subside once you stop using milk thistle. Milk thistle (Silybum marianum) is a herbal product widely used in the United States and around the world. Brittany Lubeck, RD, is a nutrition writer and registered dietitian with a master's degree in clinical nutrition. Although milk thistle may be helpful in hepatitis C, more research is needed to support these claims. In animal studies, the antioxidant and radical-scavenging properties of silibinin in milk thistle were found to reduce tumors (16). Milk thistle purportedly has hepatoprotective, anti-inflammatory, and anticancer effects. Milk Thistle. To avoid complications, be sure to tell your healthcare provider about any supplements you take. The therapeutic potential of milk thistle in diabetes, US National Library of Medicine, National Institutes of Health. Phytomedicine. Oral ingestion of milk thistle has also been linked to abdominal fullness (or abdominal pain), anorexia (a loss of appetite), and changes in bowel habits (1). However, even if supplements are third-party tested, that doesnt mean they are necessarily safe for all or effective in general. Milk thistle is a plant whose fruit and seeds have been used for more than 2,000 years as a treatment for liver and bile duct disorders. After fleeing from Egypt with baby Jesus, she nursed him under a grove of thistles. Dosage is also typically listed on the nutrition label of supplements. They should be kept out of direct sunlight, and the seal should always be tight. Nouri-Vaskeh M, Malek Mahdavi A, Afshan H, Alizadeh L, Zarei M. Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: a randomized controlled trial. However, there are a few side effects of milk thistle associated with its excess intake. A service of the National Library of Medicine, PubMed contains publication information and (in most cases) brief summaries of articles from scientific and medical journals. You may report side effects to FDA at 1-800-FDA-1088. Check out our. Check with your physician if you have any of the. It found that cholesterol levels were lower in people taking milk thistle to treat diabetes than those taking a placebo. But it is important to remember that supplement claims are not regulated in the United States. Milk thistle is promoted as a dietary supplement for hepatitis, cirrhosis, jaundice, diabetes, indigestion, and other conditions. As with any natural remedy, people should discuss using milk thistle with a doctor before taking it. Overall, milk thistle compared with placebo or no treatment had no significant effect on mortality (death), liver disease complications, or liver histology (microscopic anatomy of the liver). Seeff, L.; Curto, T.; Szabo, G. et al. Scientists think this creates a detoxifying effect, which is why milk thistle may be beneficial for liver problems. Get emergency medical help if you have any of these signs of an allergic reaction while taking milk thistle: hives; difficult breathing; swelling of your face, lips, tongue, or throat. 2005 - 2023 WebMD LLC. content is best viewed in IE9 or above, Firefox and Google Chrome browser. It is not yet clear whether milk thistle is equally beneficial for bone loss with a different cause. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Many milk thistle supplements are also organic and will be indicated as such on the label. Therefore, it is not known whether milk thistle or silymarin should be used to treat cirrhosis. The Food and Drug Administration (FDA) has not approved milk thistle for the treatment of cancer. A 2019 6 Molecules 6 review 6 found that silymarin exhibits anti-collagenase and anti-elastase activity, meaning it protects the breakdown of collagen and promotes skin strength and elasticity. 2015;22(2):290-296. doi:10.1016/j.phymed.2014.12.010. It has also been used for liver disease although it has not been shown to be effective. Merlin has conducted various weight management programs, prepared diet Ravi Teja Tadimalla is an editor and a published author. Others may find them inefficient, while some people swear by them. Gufford BT, Chen G, Vergara AG, Lazarus P, Oberlies NH, Paine MF. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. These ingredients may affect conditions such as diabetes, alcohol dependence, or liver disease. Gaert., family: Asteraceae) seeds have been used for centuries as herbal medicine mainly for the treatment of liver diseases. Eighteen clinical trials of 1,088 participants were assessed. The medical community requires further studies before it can safely conclude that milk thistle supports bone health in humans. Common Names:milk thistle, Mary thistle, holy thistle, Latin Names:Silybum marianum, synonym Carduus marianus. The terms "milk thistle" and "silymarin" are often used interchangeably. 2015;22(2):290-6. doi:10.1016/j.phymed.2014.12.010. Gillessen A, Schmidt HH. Call your doctor for medical advice about side effects. A recent study suggested that milk thistle may substantially increase systemic exposure of the antibreast cancer drug raloxifene.1. A double-blind controlled study. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. If your condition lasts or gets worse, or if you think you may have a serious medical problem, get medical help right away. U.S. Department of Health & Human Services, 9000 Rockville Pike Bethesda, Maryland 20892, U.S. Department of Health and Human Services. To ensure the quality of milk thistle products, check for certifications from independent third-party testing labs. The name "milk thistle" derives from a feature of the leaves, which are prominently banded with splashes of white. jaundice. It may not be safe for people with hormone-sensitive breast cancer. It also seems to have antioxidant and anti-inflammatory effects. Clinical practice shows that milk thistle has a good anti-liver injury effect and can be used to prevent anti-tuberculosis drug-induced liver injury. (2021). 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